They estimated 6.7 million patients eligible annually.
I said ~7 million.
Feels like a good estimate.
This is what I wanted you to look carefully at.
It looks like ICER estimated 33,522,000 patients.
They divided that by 5 because:
For each treatment, we assumed equal uptake over five years, with treatment duration ranging from one year (for the year-five cohort) to five years (for the year-one cohort). In other words, patients initiating therapy in year one would accrue all drug costs and cost offsets over the full five years, but those initiating in other years would only accrue a proportional amount of the five-year costs.
"equal uptake over 5 years" would be:
Year 1: 6.7 million patients Year 2: 13.4 million patients Year 3: 20.1 million patients Year 4: 26.8 million patients Year 5: 33.5 million patients
My read is that ICER estimates the eligible patient population in the US at 33.5 million patients. I'd really like you to have a look at that because it seems crazy.