She does have diabetes but she is secondary prevention because the trial included people with peripheral vascular disease. Read the inclusion criteria.
When you look at the inclusion criteria you will see that 80% carotid stenosis is not sufficient to establish CVD in this trial.
So, for these discussions specific to the R-IT patient populations, you may think of your mom as secondary prevention, but in reality she is not even primary prevention.
Isn't 80% carotid stenosis greater than 70% stenosis as defined by the REDUCE-IT protocol (emphasis mine)?
CV Risk Category 1: defined as men and women ≥45 years of age with one or more of the following: o Documented coronary artery d isease (CAD; one or m ore of the following prim ary criteria must be satisfied): • Documented multi vessel CAD (one or more >50% ste nosis in tw o major epicardial coronary arteries – with or without antecedent revascularization); • Documented prior MI; • Hospitalization for high-risk NSTE ACS (w ith objective ev idence of is chemia: ST-segment deviation or biomarker positivity). o Documented cerebrovascular or carotid disease (one of the following prim ary criteria must be satisfied): • Documented prior ischemic stroke; • Symptomatic carotid artery disease with ≥50% carotid arterial stenosis; • Asymptomatic carotid artery disease with ≥70% carotid arterial stenosis per angiography or duplex ultrasound; • History of carotid revascularization (catheter-based or surgical). o Documented peripheral arterial disease (PAD; one or m ore of the following prim ary criteria must be satisfied): • Ankle-brachial index (ABI) <0.9 with symptoms of intermittent claudication; • History of aorto-iliac or peripheral ar terial intervention (catheter-based or surgical).
Two different issues here - 1) what criteria did AMRN use to define the R-IT primary prevention group, and 2) what is the medical definition of primary and secondary prevention for CVD - they're not going to be the same, and I'd bet that AMRN's definition is much tighter than the medical one, as AMRN wanted very sick patients in that group.