Replies to post #213489 on Anavex Life Sciences Corp (AVXL)

[XenaLives]

Patients' stronger response to 2-73 makes placebo response less likely, as does the biomarker measurement. Placebo responses are most confounding when response to a drug is weak.

[anders2211]

The poing TempePhil is making is that even IF there is a placebo effect within the 273 RETT trial then still there is a very strong signal

The placebo affect accounts for a drop of only 2.3 points. Assuming similar placebo affect with A2-73, there is still a very strong signal!

Therefore one can conclude that 273 is working and with a stronger dose one could assume that the effectiveness will increase.

[TempePhil]

Doc, yes your figure 3 is of the raw data, my table 3 is of the averaged values from your raw data figure. Totally agree that placebo effect is real and significant, and is part of every detailed study. Also waiting for our placebo armed study!

[Steady_T]

Doc please explain why you think there were super responders?

Since there doesn't seem to be tracking of individuals in the graphs it seems to me that we could be seeing different individuals with very high variability rates. One could be very high one measurement and very low the next. If there were several such subjects we would see the data shown in the graphs.

[McMagyar]

Too funny

[Kmadd]

One confusion I see is in the data Doc is presenting the graphs on the y-axis show % change. You dont know if the 50% change is from 10 to 5 or 50 to 25. That blurs the data. A 50% change makes it look like a "super responder", when really the baseline is just different.
Tempephil is referencing a hard score, which Anavex used, which is a better apple to apple comparison.