Replies to post #205024 on Anavex Life Sciences Corp (AVXL)

[samk]

THANKS!

[McMagyar]

What a miracle the S1r is for the human body!

[vg_future]

Great NEWS Mycroft! Thanks for posting that. I got on the call a little late and missed it.
Any discussion about the shelf registration?

TIA,
vg_future

[nidan7500]

MycroftHolmes

For those of you not able to hear the call: Missing indicated that while further study is warranted, the current thinking is that A2-73 DOES positively impact the gut. Possibly due to the same method of homeostasis.

Very, very good news. I was hoping for info on exactly this issue.

Agree.

The pieces seem to be falling in place for a CNS Gut human systems solution. Hope we see the fullest story on CNS Homeostasis and how the body may heal itself. Unclear but definitely on the table, seems positive. He seems more certain for possibly this reason. Hope this development can be accelerated. (investor 2014 was all over this from the start-well done man)

Amazing, (Gut tie) possibly illustrates just how far off the entire Amyloid thesis thing was. Never had a chance.

[sokol]

Excellent news that the indication is that AVXL 2-73 positively impacts the gut, which is a critical component of a healthy brain function.

The following is from the AAIC July 14 - 18, 2019 presentation entitled Exploring Gut Microbiota as a Source of Potential Biomarkers: Initial Results from the ANAVEX ® 2Alzheimer’s Disease Clinical Study:

•Communication between gut microbiota and the brain is a critical component of a healthy brain function–identified in studies in the last decade [1,2,3]
1.Giau, V., Wu, S., Jamerlan, A., An, S., Kim, S., & Hulme, J. (2018). Gut microbiota and their neuroinflammatoryimplications in Alzheimer’s disease. Nutrients, 10(11), 1765.2.Calvani, R., Picca, A., Lo Monaco, M. R., Landi, F., Bernabei, R., & Marzetti, E. (2018). Of microbes and minds: a narrative review on the second brain aging. Frontiers in medicine, 5, 53.3.Kowalski, K., & Mulak, A. (2019). Brain-Gut-Microbiota Axis in Alzheimer’s Disease. Journal of neurogastroenterologyand motility, 25(1), 48.

•Higher levels of microbiota families i.e. Ruminococcaceaeand Porphyromonadaceae–associated with improvedANAVEX®2-73 response at week 148 (p<0.01 and 0<0.04, respectively)

ANAVEX®2-73 may have beneficial homeostatic effect on brain-gut-microbiota axis