Anavex Life Sciences Corp (AVXL)

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Excellent news that the indication is that AVXL 2-73 positively impacts the gut, which is a critical component of a healthy brain function.

The following is from the AAIC July 14 - 18, 2019 presentation entitled Exploring Gut Microbiota as a Source of Potential Biomarkers: Initial Results from the ANAVEX ® 2Alzheimer’s Disease Clinical Study:

•Communication between gut microbiota and the brain is a critical component of a healthy brain function–identified in studies in the last decade [1,2,3]
1.Giau, V., Wu, S., Jamerlan, A., An, S., Kim, S., & Hulme, J. (2018). Gut microbiota and their neuroinflammatoryimplications in Alzheimer’s disease. Nutrients, 10(11), 1765.2.Calvani, R., Picca, A., Lo Monaco, M. R., Landi, F., Bernabei, R., & Marzetti, E. (2018). Of microbes and minds: a narrative review on the second brain aging. Frontiers in medicine, 5, 53.3.Kowalski, K., & Mulak, A. (2019). Brain-Gut-Microbiota Axis in Alzheimer’s Disease. Journal of neurogastroenterologyand motility, 25(1), 48.

•Higher levels of microbiota families i.e. Ruminococcaceaeand Porphyromonadaceae–associated with improvedANAVEX®2-73 response at week 148 (p<0.01 and 0<0.04, respectively)

ANAVEX®2-73 may have beneficial homeostatic effect on brain-gut-microbiota axis