Replies to post #232362 on NorthWest Biotherapeutics Inc (NWBO)

[marzan]

Exactly, AVIIs were fooled by the psuedoprogression phenomena that is unique to immunotherapy that was not available to the so called trial experts including FDA reviewers prior to 2015 or a little earlier, imo. Even the PIs like LL and Prins and Kims were confused by this phenomenon at the very begininning I guess and thus the crossover in L trial made LL called it possibly confounding/muddying the results. Political Science self proclaimed bioguru AF must have sniffed something from some kind of leak from that traitor DMC chair or so and poorly concluded the increase in tumor size was due to DcVax toxicity and started bashing the stock and are challenging the very integrity of the trial investigators. Alas, these AVIIs started naked shorting this stock fueld by public negativity spewed by NW who called for governance investigation, another con who tried to steal this Company cheap attempting to coup the management, all decimated the stock price to where it is now. I asked AVII in his honest opinion to tell us whether DCVax works or not; apart from trial futility or failure theory just based on the initial design with the FDA, he should honestly answer that question if he is continued to interact in this board. He has a board honesty that he needs to fulfill. Oh, he will ask what is that? If you insist Pyrr, he will declare he doesn't care about us. Ex said that too. The funny part is ICIs are approved and they don't just cause pseudoprogression but hyperprogression. I think pseudo triggers 25% enlargement whereas hyper triggers 2500% enlargement. Why not AVIIs go and spew on those BMY/MRK/AZN boards and run a procession to FDA demanding withdrawal of ICIs.

[Rootjim]

sukus this post looks to be worthy of a sticky. Could be a good reason that the hold theory needs a rest. Also running the DCVax-L trial further out, NWBO had to remain silent for confirmation..................
Also the shorts and naked shorts are fighting a difficult battle, that they have a high chance of losing.Thus the fear is high for the shorts, while the longs have a bite on their leg, like a Pit Bull. IMO

[GoodGuyBill]

I bet AVII doesn't respond or dismisses your argument by focusing on some minor bullsnit that has nothing to do with your point.

AVII,

I believe the vaccines are not futile.

Below are to refute your futility theory.

The surrogate PFS endpoint was based on the patients tumor progression. I believe that is the case.

Before:
The tumor was getting bigger ==> the tumor progressed ==> DCVax futile.

Now:
With better understanding of immunotherapy mechanisms of work which was supported by BMY:

The tumor was getting bigger ==> but oh the tumors were filled with T-cells ==> induced tumor necrosis ==> the tumors shrunk afterward ==> better quality of life ==> patients life extended ==> patients survived.

You see, they originally saw tumor progression were actually a signal that T-cells were infiltrating the tumors and secreting toxins to cause tumors to die and not spread.

Imo..

[AVII77]

AVII,

I believe the vaccines are not futile.

Below are to refute your futility theory.

The surrogate PFS endpoint was based on the patients tumor progression. I believe that is the case.

Before:
The tumor was getting bigger ==> the tumor progressed ==> DCVax futile.

Now:
With better understanding of immunotherapy mechanisms of work which was supported by BMY:

The tumor was getting bigger ==> but oh the tumors were filled with T-cells ==> induced tumor necrosis ==> the tumors shrunk afterward ==> better quality of life ==> patients life extended ==> patients survived.

You see, they originally saw tumor progression were actually a signal that T-cells were infiltrating the tumors and secreting toxins to cause tumors to die and not spread.

Imo..

sukus, that does not "refute" the futility theory, it explains it.

Look, going into that interim in the summer of 2015 the primary EP was PFS assessed by modified RANO (Macdonald + Flair).

If they know the comparative efficacy results for that (from having performed an interim and receiving a futility rec) then it is too late to try again with a different progression assessment method. (they can change it, but the results would be exploratory rather than confirmatory).

If they do not know the results then it is fine to change the assessment method.

Obviously I think they know the results (and simply knowing the original EP was futile is enough knowledge to make any changes exploratory).