Replies to post #182390 on Amarin Corp Plc (AMRN)

[massulo52]

A lot of people that cannot tolerate statins may be Vit D deficient. Statins are contraindicated with Low D

I started Crestor 10 and had pains so I stopped. Yrs ago My md told me to take D which I did not. So I read up and took 10,000IU daily for 2 weeks, then restarted Crestor and have not had pains,,

[sts66]

Yeahbutt.....R-IT patients stayed on their statins, so you can't extrapolate that data to non-statin compliant patients, which means RWE is really the only way to see if V works as standalone therapy - and that wouldn't be definitive, just suggestive. I really don't believe BP would spend the money to run a V only CVOT, too much money, would take too long, so they wouldn't have enough time left between results and gaining FDA approval to get a ROI before Teva enters the market. What I'd like to know is if the synergies of EPA + statin are due to anti-inflammatory effects of both drugs, and LDL-C is just a sideshow - meaning would someone with normal LDL-C who ordinarily wouldn't be prescribed a statin get a bigger CVD benefit from taking both drugs vs. just taking V - that would be an interesting trial, but again I don't see anyone ever finding a reason to run it.