First of all, I stated it wrong. I meant functional not dysfunctional enzyme. All I’m saying is if people are missing a functional enzyme to stop cancer, is it any wonder the CI companies instead narrow in on a more immune intact group to place their hopes in GBM for their therapy? There is a combo therapy they could instead try CI with Everolimus in PTEN mutated GBM. This would be a possible solution, albeit potential side effect increase.