What has emerged is the optimal therapy for starters following surgery is RT/CT followed by Dcvax-L. Upon recurrence surgery followed by Dcvax-L. So, Dcvax-L will see high utilization if considered top line therapy for both n and r.
Then, the hunt is to work to eliminate RT/CT, which may or may not be required since the majority of the tumor debulking is accomplished in most GBM cases via surgery and since surgery is required for L.