Replies to post #214024 on NorthWest Biotherapeutics Inc (NWBO)

[iwasadiver]

Also remember that mouse models at UCLA showed advantage with combining vaccination with PD-1 inhibitors. Don’t get disappointed. This will come sooner than you think I believe.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951098/

[CaptainObvious]

A little over a year. Doesn't sound impressive to me.

[longfellow95]

I was about to fire off a 'disgusted of Tunbridge Wells' post, until I saw this was recurrent!
But as Cog says, all the normal provisos apply.

Plus if you are eligible for a resection after recurrence, then you have a better life expectancy than those who aren't eligible due to tumor location or new growths.

Quite a few LTS's have had 3 or 4 resections and managed to stay a step ahead of the disease.

I don't know if these subjects received Bev because that caps survival after recurrence at 9 or 10 months...

It's promising, but nothing too special.

[Know-Fear]

Does make one wonder about the possibilities (starting and effacacy) of combo trials.

[TopelRoad]

Hi Longfellow95,
Open label treatment for recurrent GBM:
16 patients saw treatment benefit, they had Ketruda before surgery.
19 patients did not see treatment benefit, they had Ketruda after surgery.
The study is reporting an average instead of a mean. Including a min/max would be helpful.

Overall, pretty cool -- I wonder why pre-surgical treatment would make a difference?