I think the operative metaphor is “Throwing spaghetti against the wall to see if anything sticks.” Sorry if the use of this phrase to critique ICI trials is cliche on the mb — that’s one of the problems with joining a multi-year conversation in the last couple of months!
"Ipi" is probably being looked at to possibly benefit from a preexisting immune response. Due diligence says DCVax-L has this correlation. Best wishes.