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meirluc

01/13/19 9:01 PM

#208261 RE: ae kusterer #208230

Kustere, you probably asked for an estimate of how many of the 331 were alive at 3/17 (not 3/31/18), the time that the information was collected for the publication of the blended data which first saw light on 5/29/18. The publication stated that 108 were alive at 3/17 so we don't have to guess the survival numbers at 3/17.

We were also told at a 6/17 meeting that the average attrition rate was reduced to 2 per months. Since the attrition rate slowly diminishes with time I will make the wild estimate that the attrition rate for the 20 months between 3/17 and 11/18 was around 1.5 per months or 30 patients. Therefore by 11/18 we may have had about 78 survivors (108-30=78). If this estimate is close to the truth, we are likely to have close to the same number of survivors now since only 2 months passed since 11/18 and the attrition rate now is probably minimal.

Of course this is only my estimate and may be off target. I know that we cannot have 93+ survivors today because only a total of 93 reached 36 months. Although 78 survivors seems a reasonable number I am more comfortable with a survival range. Let's say that I am about 80% sure that
we have today anywhere between 65 and 80 survivors.