Replies to post #207179 on NorthWest Biotherapeutics Inc (NWBO)

[jondoeuk]

One of the reasons those TAA vaccines failed is due to low affinity TCRs https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201242606 When you target neoantigen there is no central tolerance, so cells will bear high avidity TCRs and there will be minimal risk of autoimmunity.