NorthWest Biotherapeutics Inc (NWBO): One of the reasons those TAA vaccines fa...

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Re: CogDiss 1188X post# 207179

Monday, 01/07/2019 8:00:10 PM

Monday, January 07, 2019 8:00:10 PM

One of the reasons those TAA vaccines failed is due to low affinity TCRs https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201242606 When you target neoantigen there is no central tolerance, so cells will bear high avidity TCRs and there will be minimal risk of autoimmunity.

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