Replies to post #206357 on NorthWest Biotherapeutics Inc (NWBO)

[sentiment_stocks]

Well and 10 is half way to an adult whereas 16 is more like two thirds the way to an adult... yielding a “teenage” dendritic cell.

[Doc logic]

flipper44,

Further purification of the DC product will also reduce signalling interference in the next trial patients, proper spacing will maintain proper signaling levels throughout the treatment regimen and an agonist will improve initial uptake. Best wishes.

[CogDiss 1188X]

Thanks Flipper - hadn’t seen this particular data before on method B. In combination with adjuvants and other treatments like ICIs, etc, DCVax-Direct has great promise to be sure. Ultimately many cancer patients face the issue of inoperable tumors. Chemo/radiation can provide some palliative help but typically fails. Effective immunotherapy offers a distinct chance to be curative as opposed to just palliative.

I believe NWBO is looking at sarcoma as one of their first indications, since they saw a number of good responses in that type of cancer. I wonder if they also chose sarcoma because of Dr Coley’s experiences treating it with admittedly rather primitive but apparently effective immune-based treatments. Good work by Coley done over 100 years ago.

An overview for those not familiar with his work:
https://www.cancertutor.com/coleys-toxins-immunotherapy/

A more extensive consideration from the British Medical Journal,
“Dr William Coley and tumour regression: a place in history or in the future ”
https://pmj.bmj.com/content/79/938/672

Interesting quote the above article appeared in a George Bernard Shaw play from 1906 called The Doctor’s Dilemma:

“Drugs can only repress symptoms: they cannot eradicate disease. The true remedy for all diseases is Nature’s remedy .... There is at bottom only one genuinely scientific treatment for all diseases, and that is to stimulate the phagocytes. Stimulate the phagocytes. Drugs are a delusion”.

Unfortunately we lost many decades banging our heads against the wall trying to get chemo to work better instead of pursuing immunotherapy. FYI - this is not revisionist history. Many people outside the mainstream have long believed the immune system plays a key role in recovery from cancer, no doubt due to Coley’s work.