Replies to post #167221 on Anavex Life Sciences Corp (AVXL)

[jimmy_mcyoloswag]

Which very likely have significantly different calcium buffering workloads (DA SNc neurons move around much more cytotoxic intracellular free calcium due to their electrophysiological profile) and thus should have different parameters for calcium homeostasis mediated by *drumroll* mitochondria and the ER:

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2007.00293.x

[Investor2014]

“ In essence, activity-related cellular Ca2+ load, mitochondrial DNA deletions and mitochondrial dysfunction, as well as oxidative and metabolic stress are particularly important trigger factors for PD”

This may be the common denominator between PDD, AD and other neurodegenerative diseases that is addressed by the MOA of A2-73.

But I don’t really know enough to make the argument and will have to wait and see AD protocol information just like everyone else.