Replies to post #153341 on Anavex Life Sciences Corp (AVXL)

[nidan7500]

dynamic complexities of the human body that represent the still poorly understood bigger picture of how people stay well, get sick or get well.

We may say at some point that we were there when the discussion on, "The dynamic complexities of Precision Medicine in CNS", was brought up in a rational and object manner.

For now, if we can use genetic pre-dispositioning and genomic-biome clinical facts and rational to identify patients who are likely to respond to treatment, and then prove it, then the rest will follow. IMO.

I also do think he has a few other bombs to drop at AAIC.

[falconer66a]

Not All Investors Unable to Understand the Science

I would argue that the "dynamic complexities" of CNS diseases should cause investors to be highly skeptical of the simplistic notion that "restoring cellular homeostasis" by A273 will cure CNS diseases, cancer, pain, high cholesterol, insomnia, high blood pressure, etc.

For investors unable to comprehend the complexities of the efficacies of Anavex drugs demonstrated and proven in murine subjects, they should stick, perhaps, with the most mundane of equity investments. A Microsoft, Amazon, or the like?

Those with any skepticism at all regarding Anavex in particular, and new pharmaceuticals in general, have no business in risking hard-earned dollars in equities such as AVXL.

Fact is, however, the skeptics have been selling off for how long, now? Those who thought Anavex will be a failure have liquidated their positions. Those holding, with “strong hands,” such as the several institutional owners (with substantial positions) are not “skeptical.” They comprehend both the science and profuse papers affirming the future of Anavex molecules and the company.

[jimmy_mcyoloswag]

The key is not "cellular" homeostasis but intracellular calcium homeostasis.
https://www.hindawi.com/journals/ijcb/2010/546163/

Neurons cycle a lot of calcium across their membranes for neurotransmitter release and activity regulation, hence their susceptibility to neurodegenerative calcium toxicity. Same as the heart muscle.

[XenaLives]

Actually I'd settle for improvement and then slower decline. I wouldn't expect a "cure".

I don't think anyone here holds the "simplistic notion" that you claim.