i agree jimmy, nice article; here is the link to a more recent article; "Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways"
Dysfunctional mitochondria have a major impact on neurodegenerative diseases. For instance, in Parkinson’s Disease (PD), metabolic stress and mitochondrial damage can affect the viability of dopaminergic (DA) neurons in the substantia nigra [1–4], and a-synuclein aggregation, a hallmark of PD, has been strongly associated with mitochondrial dysfunction [5–8].