Mild impairment = damaged neurons...not dead. Moderate = more dead neurons. Damaged can be repaired with a2-73. The dead neurons cannot be brought back to life.
“If we determine that our BACE1 inhibitor can prevent or delay the onset of symptoms in healthy yet high-risk populations, this would represent a tremendous breakthrough for those that may face this debilitating disease.”
In fact Anavex selected MMSE>20 as "early", while it sounds like the companies above may target "healthy", MMSE>24 as early. BP is suspect. Anavex is not.