Replies to post #124384 on Anavex Life Sciences Corp (AVXL)

[frrol]

The dosing has never been explained as far as I know. It appears that the AAT poster was wrong or the dosing changed and the company didn't say anything. But it is clear that there are now 10mg dosings and no explanation why. Of course, this change enabled dosing dependency analysis in the Part B, which is good, but it begs the questions: How did participants agree? Did some have tolerability issues? Or how were the 10mg folks chosen (selective bias concerns)?

[seventhwave]

F1ash, your quote referencing their poster describes Part B while I was alluding to Part C. I was using your clarification there, that Part C is really a completely new trial to speculate that it would give them the freedom to adjust the lower doses. I assumed that they were constrained from doing so by Part A + Part B protocol and not patient tolerability. If they attempted to titrate up and reached the tolerability bounds earlier then my guess of their flexibility to do so in Part C is redundant.

Separately, I'm not sure why Dr. Perry said that the case of a drug improving or benefiting patients through a long period has never been witnessed before when you have shown results from the Flurizipan study in detailed charts, clearly showing about a good 18% showing retained improvement at the 12 month interval.

I'm not sure why Dr. Perry was on the call (as 3rd party) in the first place. It's as if Missling were implying "if you don't believe in the data or what Anavex is saying then listen to this editor of the Journal of AD". Esp. when he has a galaxy of stars in the Anavex SAB. Beats me.

[McMagyar]

really the only negative side affect that has
translated is dizziness. patients in the throws fo alzheimers may have a more difficult time comprehending that the dizziness
is what is proving effect..

sometimes the caregivers have to make tough decisions..upping the dosage may make you uncomfortable now..but if it gets the concentreation level up..we know what happens next..

like someone turned on a light..