frrol Thursday, 10/12/17 10:43:05 PM Re: F1ash post# 124384 0 Post # of 145455 The dosing has never been explained as far as I know. It appears that the AAT poster was wrong or the dosing changed and the company didn't say anything. But it is clear that there are now 10mg dosings and no explanation why. Of course, this change enabled dosing dependency analysis in the Part B, which is good, but it begs the questions: How did participants agree? Did some have tolerability issues? Or how were the 10mg folks chosen (selective bias concerns)?