Replies to post #115718 on Amarin Corp Plc (AMRN)

[rafunrafun]

I don't need to remember, I'll just quote you:

"you are ignorant of the fact that Jelis had meaningfully more deaths in the treatment arm"

Lets just stick with facts. 265 vs 286, P = 0.333 Let's repeat...

You: "...meaningfully more deaths"
Fact: P = 0.333

So after I just proved you lying (meaningfully & 0.333), what exactly is your point? Are you trying to say that in RI, significantly more people will die in the Active arm? Then surely the safety committee aren't doing their jobs, because they met probably 22 times to check for SAFETY and every time recommended for the trial to continue.

[oneragman]

I,
All cause death!? Are you serious?

[jessellivermore]

OK..iwfal...

Gotcha..Interesting...I have not seen those figures probably beccause I did click on that screen...All cause mortality...control arm 265 active arm 286.

Interesting...but not meaningful..And this is the reason its not meaningful..and it is a reiteration of what I said before...

There were a total of 551 deaths in JELIS which was designed as a CVOT trial..but something was pretty strange about the trial. That being there were only 60 deaths directly related to heart disease...35 in the so called sudden coronary death and 25 from Fatal MIs...

You understand of course that CVD is accounting for just over 13% of the deaths in this trial...Looking at stroke we get pretty much a wash helps ischemic strokes hurts hemorrhagic stroke (the guys on anticoags). So what's killing off the the remaining 85%...Maybe all those late nights with the SAKI bottle in all that cigarette smoke...Maybe a bad meal at the FUGU restaurant..we do know gastric carcinoma is a big deal (bigger than CVD???) and maybe EPA doesn't work too well on GC. This is the same kind of thing you might see in a trial for acne cream...if you were foolish enough to be rating the study on "All cause mortality"..This wont translate over to R-I where CVD deaths are going to be way north of 13%...

Nice try though...

?>) JL

[staccani]

In Jelis the AA/EPA ratio decreases from a an already optimal 1.6 to 0.8 and yet provided a 19% MACE RRR, which was quite astonishing IMO, as you would not expect to see any difference between those already optimal levels. For such healthy population you would not expect a significant difference in deaths between the two arm and as a matter of fact very few died of CDV in this trial and we know that in general Japan has a very low CVD mortality. Why? Because they have a very low AA/EPA ratio!

From various readings it appears that average US citizens have an AA/EPA ratio above 15, 10 -15 times bigger ratio than avg Japanese. It is not astonishing that in USA CVD is the first cause of death by far and that RIT MACE composite rate is almost 10 times bigger than Jelis (4.7% pa vs 0.6% p.a)

RIT was designed to try and achieve (more than double Jelis dosage) a AA/EPA ratio closer to Jelis (also because the more EPA incraseas the more AA reduces as they both compete for the same receptors, so EPA intake has a double effect on numerator and denominator of the AA/EPA ratio) and we know that this is going to make a big difference in terms of CVD mortality and MACE from countless published studies we had in the last few years.

These are the facts, the rest is noise.