Replies to post #1331 on Vascular Biogenics Ltd (VBLT)

[Oren1976]

Look at my last simple calculation how we know primary endpoint was met. If we assume 25% alive by now if all 256 lived avastin period meaning 75% sadly died then we already met primary endpoint. If we assume 65% sadly died giving avastin a lot of credit then primary endpoint will be met around December this year. And CEO said we are going to next year to reach 189 events so any way u look at it primary endpoint was or will be met

[gr8db8]

Thank you, wcopeland, that was my exact thought. The information is there in the Sept presentation. Click on it. Open it. Read it. It's not so hard. The presentation was shared a long time ago.

For the newbies, do some research. Search the older discussions. Chances are, we have exhaustively discussed it. It may be new to you but many of the posters that have been here for a while have discussed it already.

If you don't find it, respectfully discuss it. No need to be sarcastic or arrogant about it.

[staccani]

Wcpopeland the only trial you mention above 10 months OS was a very small trial (29 patients, link below) . You should know that small trials have sometimes unusual results and that is why you need to do bigger trials to have a statistical significant results to get any drugs approved (ph3)

On bigger numbers Avastin MoS should fall back on 8-9 months average.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448378/

'I imagine that if you really cared, you could track when patients pass away via social media and other web stalking techniques. I am not a fan people who do that, but between Facebook, Inspire, etc. it should be possible to "estimate" individual patient trajectories' This approach to me has nothing scientific, cannot be proved . If I were a neurologist I would simply try to call or meet one or more of the doctors partecipating to the trial to exchange useful medical experience.

'I personally know of 2 people who have passed from cancer (one from GBM) because they just did not care for the quality of life impact that is associated with fighting. It happens, even if they are not too sick to travel' That is an unfortunately but personal choice. In any case this does not tell us anything about VB111 efficacy, they would be accounted for drop outs from the trial