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Re: wcopeland post# 1331

Tuesday, 09/26/2017 1:08:54 AM

Tuesday, September 26, 2017 1:08:54 AM

Post# of 2099
Wcpopeland the only trial you mention above 10 months OS was a very small trial (29 patients, link below) . You should know that small trials have sometimes unusual results and that is why you need to do bigger trials to have a statistical significant results to get any drugs approved (ph3)

On bigger numbers Avastin MoS should fall back on 8-9 months average.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448378/

'I imagine that if you really cared, you could track when patients pass away via social media and other web stalking techniques. I am not a fan people who do that, but between Facebook, Inspire, etc. it should be possible to "estimate" individual patient trajectories' This approach to me has nothing scientific, cannot be proved . If I were a neurologist I would simply try to call or meet one or more of the doctors partecipating to the trial to exchange useful medical experience.

'I personally know of 2 people who have passed from cancer (one from GBM) because they just did not care for the quality of life impact that is associated with fighting. It happens, even if they are not too sick to travel' That is an unfortunately but personal choice. In any case this does not tell us anything about VB111 efficacy, they would be accounted for drop outs from the trial
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