Vascular Biogenics Ltd (VBLT)

[wcopeland]

There is a lot of bluster and bravado that really seems unnecessary.

staccani: you mention trials where Avastin survival ranged from 7 to 10.5 months. Please cite any specific triala that Was above 10 months other than the well known nivolumab bmy trial where we know the reason (only small tumors di nrolled and btw and avg survival btw Was 10 months not 10.5)

This is the perfect example of your arrogance. That information is easily available, and the most recent place it has shown up is in the Sept 2017 VBLT Presentation (http://ir.vblrx.com/events-and-presentations/presentations). Reference slide #21 out of 40. VBLT has already very clearly listed that in their pooled Avastin analysis the following trials have exceed 8 months mOS:

Nagane (2012): mOS = 45.7 weeks (10.5 months), n=29
BRAIN (2009): mOS = 40.5 weeks (9.3 months), n=85

As davidal66 warned, historical pooled data has its flaws in that any given trial has a small (but real) probability of bucking the trend.

oren1976: Now that we all know primary endpoint is already met let's see where it goes. I think they should stop the trial and start treating everybody with vb111

Did I miss something?!? How are we speaking in absolutes about the primary endpoint being met? Is this because of staccani's infallible data?

I really hope we do not go down the road of most stock pumpers who get caught up in their own self-validating logic. I agree that there is a significant chance the primary endpoint will be reached at end of Sept, but can we please stick in the realm of reality?

staccani: "how could you underestand from direct experience of these 11/12 patients in vbl that they survived 10 months? Nobody is able to self report his/her survival."

I imagine that if you really cared, you could track when patients pass away via social media and other web stalking techniques. I am not a fan people who do that, but between Facebook, Inspire, etc. it should be possible to "estimate" individual patient trajectories.

staccani: that they would quit a trial because some had to fly. I have had direct experience of cancer trials and nobody would leave his only survival chance unless he becomes too sick to travel. But that applies to both arms

I personally know of 2 people who have passed from cancer (one from GBM) because they just did not care for the quality of life impact that is associated with fighting. It happens, even if they are not too sick to travel.