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alphapuppy

09/02/17 9:55 AM

#132695 RE: exwannabe #132689

Ex

Nope nothing happened with the trial. It is part of the methodology of the modeling.

More events were posted in this model as early as possible for each graph, in order to be as to be as conservative as possible. This would in essence take out the longest potential follow ups and time factors first. Therefore, for the later dates, their would be less events than what probably actually occurred. Keep in mind that the total number of events however are accurate based on the IMUC modeling

When running my models I always like, in this situation, to look at worst case scenario's. In all probability, ACTUAL curves will be different with better survival rates then listed.

However what you need to understand, is that the actual difference between the two curves will be accurate And consistent with this modeling.

So the strength of this model is looking at the difference between the experimental arm and the placebo group.

So the actual curves probably will be slightly higher than what is shown. But the difference between the control and the experimental arm will be very similar to the modeling.

AP