Replies to post #112757 on Amarin Corp Plc (AMRN)

[bidmark]

You should probably notify Amarin.

[Krishkris]

Are you really a practicing physician? have you ever heard of HIPAA?

How can you share specific patient health info on public site.

FYI

“HIPAA” stands for the Health Insurance Portability and Accountablity Act of 1996. The HIPAA Privacy Rule, Security Rule, and Breach Notification Rule were implemented to protect the privacy of an individual’s health information and govern the way certain health care providers and health plans, also known as “covered entities” collect, maintain, use and disclosure protected health information.

[couldbebetter]

ralphey, the 2 follow-up readings were substantially lower, if they happened to spike to an all time high I would ask if how soon and he ate in the day before his testing. I would also see if on his next scheduled test if it would revert back to the lower levels he had before. (I would also ask him if for any reason prior to that test if he had reduced or stopped using his medication for a time. I would also wonder if he was on any statin meds or had any other changes in medications or life style. Good doctors are like detectives solving crimes,but in both cases the data has to be valid to come out with a good diagnosis. Sometimes perps lie to detectives and patients lie to their doctor.

[kvenne]

Ok since I liked my pet rock so much I will bite.

The diagnosis of this patient is they did not fast before their last blood work was taken therefore skewing the Trig. results.

I do notice you have a lot of spare time on your hands to be posting on our little old AMRN investor page and I second the notion that your writing is terribly hard to read. I thought doctors were to busy to come and helps us poor chumps out in seeing the error of our ways.

Another RWE is my mother on Vascepa since 2014 Trigs are down from 353 to 160. It took close to a year of taking Vascepa before she was able to achieve these results and maintain them to this day.

[rafunrafun]

Thus far you are actually making a case for proving that vascepa works. As I have stated many times, it is indisputable that vascepa lowers TG, see marine and anchor results.

The only question that remains outstanding is whether TG and other biomarker lowering reduces CVD. From what you have said thus far, your 'patients' are alive and well!

So are you actually trying to prove that vascepa works (reduces CVD)? You seem to be doing a good job, as you haven't said that anyone has had a CV event.

[Whalatane]

Ralphey ...Thx for posting your observations and yes I believe you are an MD ..upstate New York from memory and living in a semi rural area.

So my comments ...haven't read all the posts so I may be repeating something.

1) Vascepa is not the best at lowering TG's ...thats well documented ....however it is the best at lowering TG's without raising LDL cholesterol ...which is important for Hetero FH CAD patients like myself.

2) The CAD risk reduction in JELIS was seen with only very modest reductions in TG's. Vascepa ( EPA ) benefit appears largely to be anti inflammatory ....the main reason I take EPA

3) In 2016 I underwent a Cardiac Cath to determine extent of coronary plaque build up .....not enough to require stents but enough to require max Statin dose , Zetia , Med diet , lots of exercise etc etc .
The Interventionist who did the Cath suggested I stay on Vascepa ..or if my insurance didn't cover ..on Omegia Via EPA 500 .
The reason he specifically stated ..." for its anti inflammatory qualities "

4) I've had more lipid panels run since 1986 then probably this whole board combined ( yeah lucky me ..:-).
I can move my TG's around by almost 100 pts depending on wether I skipped my meds for a couple of days and then splurged on corn and red wine the night before the blood draw...or stay on my meds , fasted at least 12 hrs before the blood with no alcohol for 2 days before that.
Thats how much TG's can vary

5) My current view on Vasvepa is that it will see demand ( provided insurance covers ) for those following a PCI ( stented ) or with very high TG /low HDL combination ...ie many diabetics..
Beyond that the same degree of benefit can probably be achieved by optimizing the Statin dose , and a Med diet / regular exercise / no smoking routine.

Thxs for contributing your experiences to the board
Kiwi
ex FDA petition group following SPA rescinding and Adcom decision

[Whalatane]

Ralphey can you offer more details on this patient

"
patient age 45 started vascepa 2013 trigs 409 - fu readings 294 284 reading today 411 yes they are taking med as prescribed - just an isolated case - many possibilities why this occurred .."

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My understanding of the above ...2013 ...TG= 409 , prescribed Vascepa 4gms so reading in 2014 =294 , reading in 2015 = 284 .....reading in 2016 ? and now in 2017 reading = 411

Is that correct ?
So the readings in 2014 and 2015 would be consistent in what you would see starting with a TG level of 409 and reducing that roughly 30% with 4gms of Vascepa daily .
If the reading is 411 in 2017 I'd be inclined to make sure he was taking his/ her Vascepa ( and all the other prescribed meds ) and then request another lipid panel after a 12 hr fast ......with low fat no alcohol meals for at least 2 days prior.

Any family history of CAD ?
What was the patients LDL and HDL levels ?. Are they diabetic or have metabolic syndrome ?
Is the patient on Statin therapy , if so which Statin and what dose ?

I'm sure you are a busy MD but if you have time I'd appreciate more info on this patient .
Any way of tracking if they refilled their scripts regularly and on time .
In my case, Kaiser tracks my scripts and starts texting me , emailing me and finally calling me if I don't refill on schedule
thx

Kiwi