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Replies to post #103237 on Anavex Life Sciences Corp (AVXL)
blu_1
04/27/17 4:48 PM
#103242 RE: amstocks82 #103237
OFP
04/27/17 7:20 PM
#103258 RE: amstocks82 #103237
Overexpression of Sig-1R-EYFP (Figure 5E) or wild-type Sig-1Rs (data not shown), however, suppressed ER stress-induced activa- tion of sensor proteins PERK and ATF6 (Figure 5E). It is unclear at present why Sig-1R overexpression did not af- fect the activation of IRE1. Nevertheless, because ER stress longer than 30 min can cause the redistribution of Sig-1Rs to the entire ER (Figure 5D), it is possible that re- distributed Sig-1Rs may play a role in the suppression of misfolded proteins that cause UPR. Inasmuch as Sig-1Rs can suppress UPR, we tested whether dysfunction of Sig-1Rs might affect cell death/ survival. Results showed that knocking down of Sig-1Rs significantly enhances apoptotic cell death induced by ei- ther TG or glucose deprivation (Figure 5F). Taken together, the above data confirm the chaperone nature of Sig-1Rs at the ER.