Replies to post #102417 on Amarin Corp Plc (AMRN)

[HDGabor]

JL-

Why don't you stick to business issues and leave the medical stuff to me

Why don't you
- stick to (take) your pill
- read and understand my post
before write the usual, Übermensch, nonsense sentence ... I do not have sophisticated language like j-, so it could not be a problem for you ... or is it?

- I wrote "Addition" ... not "But"
- It wasn't a "medical stuff" it was facts ...

Please enlighten me which part of my post isn't true ... We already have one Pyr on the board we don't need another...

Why don't you stick to medical stuff and leave the business issues (e.g. GIA or BO) to us ...

Best,
G

[jessellivermore]

Lipids and CVD risk...

The important point which my posts may not have clarified is that looking at lipid levels as isolated lab values may not offer that much insight into the magnitude of CVD event risk..

Lipids need to be viewed against the background of systemic inflammation. A molecule like DHA might actually lower triglycerides more on a per dose basis than EPA; and elevated trigs might increase CVD event risk, but that does not mean that DHA itself is more effective at lowering CVD event risk than EPA..EPA also acts to lower systemic inflammation and DHA does not and therefore EPA is much more effective in lowering CVD risk..

This failure to include the systemic inflammation background has lead to the confusing data that surrounds lipid studies and their effects on CVD..This is what the cardiac community has not factored in when considering EPA...EPA does have lipid lowering lowering properties, but the other pleotropic effect principally lowering systemic inflammation is the the most important..

":>) JL