Amarin Corp Plc (AMRN)

[jessellivermore]

Lipids and CVD risk...

The important point which my posts may not have clarified is that looking at lipid levels as isolated lab values may not offer that much insight into the magnitude of CVD event risk..

Lipids need to be viewed against the background of systemic inflammation. A molecule like DHA might actually lower triglycerides more on a per dose basis than EPA; and elevated trigs might increase CVD event risk, but that does not mean that DHA itself is more effective at lowering CVD event risk than EPA..EPA also acts to lower systemic inflammation and DHA does not and therefore EPA is much more effective in lowering CVD risk..

This failure to include the systemic inflammation background has lead to the confusing data that surrounds lipid studies and their effects on CVD..This is what the cardiac community has not factored in when considering EPA...EPA does have lipid lowering lowering properties, but the other pleotropic effect principally lowering systemic inflammation is the the most important..

":>) JL