Replies to post #93980 on Anavex Life Sciences Corp (AVXL)

[MycroftHolmes]

Re: SR1 / ROS

A signal to do what and by whom? Why is a signal even needed during basal conditions? I just don't understand why the sigma receptor would want to generate reactive oxygen species (ROS) at any time? What does that trigger and why (during basal conditions)?

Why oxidative stress is sometimes good is the interesting question to ask. Consider the following quote:

Increased oxidative stress has been associated with the aging process. However, recent studies have revealed that a low-level oxidative stress can even extend the lifespan of organisms. Reactive oxygen species (ROS) are important signaling molecules, e.g., being required for autophagic degradation
http://www.mdpi.com/1422-0067/14/2/3834

Where does ROS come from?

Reactive oxygen species (ROS) are generated by multiple conditions and sources, including sustained neurotransmission (e.g., of glutamate, dopamine, or serotonin), mitochondrial dysfunction, and production by glial cells
http://www.sciencedirect.com/science/article/pii/S1347861314000267

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In most cases oxidation is considered a negative. However, as the above points out, it can be important for some processes.

The biologists can correct me but I wouldn't overstate the direct relationship between the SR1 and ROS. To my knowledge ROS is a result of an over expression somewhere in the system which eventually causes an imbalance to activate the SR1 and the SR1 restores homeostasis which downstream reduces ROS.

This picture does a good job of conveying the SigmaR1 influences in a system. ROS and NOS would result when some of these cycles lose equilibrium


Cheers

Mycroft