I think all that the A+ researchers are saying is that they don't see why this particular Sigma-1 receptor agonist would work when other SR1's have not in the past. I picture this as a cursory response immediately produced without looking into the data presented by Anavex. A query from a support group head couldn't deserve any more time. I don't think they have looked into its combined effects on SR1/M1/M2/M3/NMDA, Ca/Cl/Na channels as you pointed out in post# 92445.