Out of place? I'm not even a bio guy Doc, and you apparently are. You are probably a real M.D.. Your feedback is certainly welcome.
But do the macrophages select only self-antigen activated DC's to phagocyte/eat/pacman? If so, that would be great! That would help the alleged crowding of the DC pathways.
T-Cells know the difference between a self antigen and a neoantigen... ie they know only neoantigens and ignore self antigens. DC's, unfortunately, do not know the difference, as far as I know. If there is a congestion problem in the migratory pathways during DCVax-L treatment, then that is likely the reason. But Macrophages... do they know the difference between DC's programmed for self antigens and DC's programmed for neoantigens?
Regarding the multiple low dose administration of DCVax-L, I guess the remaining question would be whether they just reduced the alleged problem of congestion of the DC's during migration, or did they effectively solve the problem?
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