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AVII77

03/25/16 4:27 PM

#75691 RE: amarininvestor #75689

Pretty much I just realized we know a lot less than we would like about the chances of interim stop.



First off, the 967 events will all be first occurrences. So that doesn't change anything wrt trial powering.

My only point was dividing 967/20,000 does not give you anywhere near the fidelity required to estimate the blended primary event rate with any meaningful accuracy.