Wow! It doesnt seem fair for the trial... Just imagine, as I said, that there is a 40% of dropped outs... Maybe it is not likely but nonetheless possible... Then reaching 192 events may take ages... Using my model, it is like instead having a 582 patient population we have 582 x 0.6 = 350 "enrolled" patients. For a 15months Bavi MOS we may have to wait well into the summer.
Any idea of which could be a reasonable percentage of dropped outs?