Replies to post #30872 on Anavex Life Sciences Corp (AVXL)

[raptors1994]

what are these two different abstracts your talking about.. i only saw the one released today

[Cbdpotential]

Great point.
As far as I know about the science.. That would make sense.

This drug changes the brains behavior, but the brain must do its own repairs.. More time = more repairs.

It's a novel approach.

It would be very interesting to see what 2-73 does for sleep deprivation... ;-)

[JB3729]

Your "another interpretation" is exactly how I interpreted the abstracts. I'm looking forward to a great presentation Saturday.

[WolfWayne]

"Putting the two (versions of the abstracts) together, this is what I read: after 5 weeks the average MMSE showed improvement in the majority of patients. After 12 weeks, the average MMSE showed improvement in a significant majority of the patients"

Brilliant!!! Will share elsewhere :)

[kc2code]

your interpretation is perfect!

especially seeing that 5 weeks referenced is 35 days and at the end evaluation of part A so they wanted to show that improvement of the majority after only 11 days oral and 11 days IV treatment.

Then another 12 weeks of part B ( 17 total ) showed improvement in the SIGNIFICANT majority...

That is it exactly imho. Great Analysis!

thank you!

[F63]

Good catch, Imho.

He will have some extry juicy details to present there, which is not contained in the abstract now.

We just have to wait.
He can give a hint with the abstract - and he did so - but he cant pack all results there into.

[shoeman6]

This actually makes sense, perhaps the decision was made (seeing as Phase 2a_b is not yet complete), to only include the complete data as discussed in the revised abstract. Only time will tell.

[Mikesc]

I think the good doctor accomplished a few things today.

- Gave us a hint of great results(1st abstract)

- Set a bear trap with a good not great abstract released to SM giving the crooks more ammo to short.

- Sent out a PR to confirm to Tutes that news is good.

The dude is amazing...

[shoeman6]

It sounds to me like the Good Doctor/Others Involved got a bit too excited about the positive efficacy data and were told to reign it in as the primary end-point at this stage is safety. We will find out over the weekend.

[NWDR]

That's how I read it.

5 weeks - majority
12 weeks - significant majority

[Jockimo]

The concern for me is why was the abstract changed?

[frrol]

I disagree with that interpretation. They said average because they're almost certainly referring to the average over the 32 patient cohort. What likely happened is some patients responded well in the the P300 and CogState but not the majority and so they cited the average, which is the most flattering light. Or they were careless in their wording. I hope it was the latter but not counting on it.

And was the improvement (in the non-majority that did improve) small? Big? Huge? Again, we should find out Saturday. That stuff matters. Big improvements in many of the folks who were on the donezepil would be great news, and entirely consistent with the abstract. Though why the abstract didn't point that out would be a boner on the company's part.