Honestly? No! As Flipper nicely explained it in one of his football analogies, direct is the real game changer. L is a proof of concept and amazing in its own right but its days are numbered before its even been approved :).
Direct is being tested on brain cancer that metastasized to the brain. I don't know if they are injecting some of those tumors directly or hoping for a systemic response. My best guess would be that they would try to make at least one of the multiple injections directly into a brain tumor (if the size and location allow) -- as well as any breast tumors (of course) and metastasized regions additional to the brain.
I also have reason to believe that at least someone in the miscellaneous phase 1 trial may be a glioma patient.
So, your theory could be tested sooner than you think.
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