We definitely need to wait for the presentation on Monday to find out where we stand. After we hear what she has to say we can debate if things are or aren't on track.
Since the presentation is after hours, if there is a PR, it doesn't have to be pre-market. It could be after hours. I am not expecting a PR, but it would be sweet to get one.
We do have an estimate for the DCM decision on the first interim analysis of DCVax-L. It's 6-8 weeks after December 10, or January 21-February 4. So that wasn't missed.
If Direct is working as we hope, then the longer it takes to get results, the better. Tumor shrinkage can start within days, but the tumor won't be gone within days, and they won't know if there's a systemic response within days. If there are going to be any patients with a complete response, I'd rather rather they wait long enough to be able to report that.
Linda already said that Direct started slowly and cautiously, as it was a first in patient trial. But it has to have ramped up by now. So maybe when we do get a PR, it will be for more than just a handful.
Originally I did want to know if the first 2 or 3 patients were showing any tumor shrinkage. But the more I think about it, the data would have been too incomplete to be of much use. Everyone, including me, would have wanted more and more updates on those patients and the next ones in the trial - it would be like watching a football game, needing to know what was happening on every play.
Also, if we had received an early PR on Direct, Linda would have been criticized for hyping premature results. Far better to be more patient (which I'm not always good at) and to wait for a PR that has meaningful stats in it.
As far as the EU sites opening, I am guessing it's "things take longer than you think" more than it is that something is wrong. We'll know more on Monday.
