NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

I also found that passage very interesting.


"It has now become apparent that DC maturation can result in either immunostimulatory or immunosuppressive DCs…"

The rest of that passage wasn't too shabby either.

"but it is generally accepted that immunostimulatory DCs produce IL-12 and express CD40 ligand (Albert et al., Nature Immunol. 2:988-989, 2001; Lanzavecchia, Haematologica 84 Suppl. EHA 4:23-25, 1999). Therefore, partially matured DC should be used for IT injection, especially if the stimuli used for maturation of immature dendritic cells are known to result in expression of CD40 ligand and in the production of IL-12."

So, they are not just maturing a large volume of dendritic cells to the right age, they are stimulating those dendritic cells to simultaneously become the right kind.

Inject the wrong type of dendritic cells, and you shut down the immune system. Inject the wrong age dendritic cells, and they can't do everything they need to do -- uptake antigens, mobilize to the lymph nodes and express biomarkers to B-cells, killer T-cells and helper T-cells.