Amarin Corp Plc (AMRN)

[drrc1949]

BioB, I managed to find your post #5913 in which you discussed EPA absorption from Vascepa and from Lovaza and you also included corresponding FDA reference material. Although my memory of the exact processes did not hold up well, I at least retained the major points.

Specifically, Vascepa causes a much higher circulating level of EPA than Lovaza/"fish oil". EPA Cmax for 2gr dose of Vascepa was 155 mcg/ml and for 4gr dose was 347 mcg/ml. EPA Cmax for 8gr dose of Lovaza was 83 mcg/ml.

Now considering PlusEPa, there may not be any study results available that establish EPA Cmax but I see no reason why I can't work out a reasonable estimate by using the Lovaza data. There appears to be a clearly linear ratio for ingested EPA to the subsequent EPA that shows up in serum.

I'll do a little more work on that later this morning and develop some numbers from that ratio based on PlusEPA dosages.