Amarin Corp Plc (AMRN)

[drrc1949]

Bio -

I am already a 4gr/daily Vascepa user. I had recalled you posting a stat on serum levels for comparable doses of Lovaza and Vascepa. The serum concentration of EPA from Vascepa was much higher than from Lovaza.

I believe you explained that this was likely because the EPA in Lovaza was partially digested in the stomach leaving a lower percentage for absorption into the blood. E-EPA from Vascepa requires metabolic action with Pancreatase for conversion to EPA. This occurs in the intestine so larger percentage available for absorption.

I've seen a few posters touting Plusepa (@90% EPA) over Vascepa. One concern is that there are heavy metals and other toxins at very low concentrations in Plusepa.....I believe any of these contaminants, if present at all in Vascepa, are at even lower concentrations. Slight positive for Vascepa!

Another concern is dosing and to judge advantages there requires knowledge of serum levels of EPA after equivalent dosages. So do 4 grams of Vascepa make more EPA available than 4 grams of Plusepa? Whatever the answer, this is an "apples to apples" comparison if the data can be obtained. Then we can extrapolate consumption requirements to achieve equivalence and thereby accurate costs for each therapy.

Plusepa looks like one of the only possible DS to compete capsule for capsule with Vascepa, in terms of EPA volume. But it's meaningless if the serum levels obtained aren't equivalent as well. That's the information I'm interested in obtaining.