DNAprint Genomics (DNAG)

[worktoplay]

How do we differ from McKeigue's work:

There is growing evidence that admixture mapping will be an effective means of gene identification. At least three independent groups have reported strong admixture linkage disequilibrium (ALD) between linked markers spaced at substantial distances (see, e. g. , Parra et al., supra, 1998 and 2001; Pfaff et al. , supra, 2001 ; McKeigue et al., supra, 2000). Given the very high levels of association that have been observed over long genetic distances, it is expected that phenotypes dramatically different between parental populations because of some genetic difference will also show associations with linked AIMs. However, as promising as that MALD approach appears, until the present disclosure, no systematic screen has been reported identifying SNP based versions of the AIMs required. McKeigue and others have identified panels of STR AIMs for use with this approach, but the use of STRs for this purpose is problematic because of the allelic complexity of STRs and the massive databases required in order to accurately estimate allele frequencies. Even small errors or faulty assumptions on the frequencies of unobserved alleles can amplify to cripple the statistical power of a study.

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