Replies to post #12878 on DNAprint Genomics (DNAG)

[worktoplay]

Ancestry 3.0?

The [ANCESTRYBYDNA] 1.0 test (DNAPrint [GENOMICS,] Inc. ) is a first version of the BGA test that was specifically designed to provide information on the proportions of ancestry at the continental level. As such, the [ANCESTRYBYDNATM] 1.0 test allowed information to be obtained as to levels of Native American, European, and African ancestry, as three component groups. The [ANCESTRYBYDNA] 2.0 test, in comparison, provides information on the proportions of ancestry at the continental level for most continents, including Native American, Indo-European (includes European, Middle Eastern and South Asian groups such as Indians), African, and East Asian (which includes Pacific Islanders, and can distinguish ancestries within Asia and the Pacific Rim. The [ANCESTRYBYDNATM] 3.0 test can further define the levels of ancestry within continents, for example, by distinguishing Japanese from Chinese, or Northern European from Middle Eastern, thus providing greater insight into where within a particular continent a person's ancestors were derived.

[[0168]] For the [ANCESTRYBYDNATM] 2.0 test, a logical grouping into four BGA delineations was made, wherein South Asian, Middle Eastern and European are grouped into a single group called IndoEuropean (see Example 2). This grouping was based on anthropological evidence and cultural connections between these groups (e. g. , their languages are derived from a common base). The results disclosed herein demonstrate that these groups are far more similar to one another in genetic sequence content than to other groups. The [ANCESTRYBYDNA] 2.0 test also performs more accurately when Pacific Islanders are grouped with East Asians. As such, the four groupings used in the [ANCESTRYBYDNA] 2.0 test include 1) Native American (i. e. , those who migrated to inhabit South and North America); 2) IndoEuropean (Europeans, Middle Easterners and South Asians such as Indians; 3) East Asians (Japanese, Chinese, Koreans, Pacific Islanders); and 4) Africans (sub-Saharan). The [ANCESTRYBYDNATM] 3.0 test can further distinguish between South Asian and European, and between Pacific Islander and East Asian, thus providing 6 proportions (Native American, European, African, South Asian, East Asian and Pacific Islander), although the confidence intervals are larger than those obtained with the [ANCESTRYBYDNA] 2.0 test. Further improvement to the tests are provided, wherein the confidence intervals are reduced. Confidence intervals around a point estimate can be reduced, thus increasing the accuracy of the test, by analyzing a complementary panel, thereby improving the confidence intervals by about 50%.

Later,
W2P

[worktoplay]

Ancestry 3.0?

The [ANCESTRYBYDNA] 1.0 test (DNAPrint [GENOMICS,] Inc. ) is a first version of the BGA test that was specifically designed to provide information on the proportions of ancestry at the continental level. As such, the [ANCESTRYBYDNATM] 1.0 test allowed information to be obtained as to levels of Native American, European, and African ancestry, as three component groups. The [ANCESTRYBYDNA] 2.0 test, in comparison, provides information on the proportions of ancestry at the continental level for most continents, including Native American, Indo-European (includes European, Middle Eastern and South Asian groups such as Indians), African, and East Asian (which includes Pacific Islanders, and can distinguish ancestries within Asia and the Pacific Rim. The [ANCESTRYBYDNATM] 3.0 test can further define the levels of ancestry within continents, for example, by distinguishing Japanese from Chinese, or Northern European from Middle Eastern, thus providing greater insight into where within a particular continent a person's ancestors were derived.

[[0168]] For the [ANCESTRYBYDNATM] 2.0 test, a logical grouping into four BGA delineations was made, wherein South Asian, Middle Eastern and European are grouped into a single group called IndoEuropean (see Example 2). This grouping was based on anthropological evidence and cultural connections between these groups (e. g. , their languages are derived from a common base). The results disclosed herein demonstrate that these groups are far more similar to one another in genetic sequence content than to other groups. The [ANCESTRYBYDNA] 2.0 test also performs more accurately when Pacific Islanders are grouped with East Asians. As such, the four groupings used in the [ANCESTRYBYDNA] 2.0 test include 1) Native American (i. e. , those who migrated to inhabit South and North America); 2) IndoEuropean (Europeans, Middle Easterners and South Asians such as Indians; 3) East Asians (Japanese, Chinese, Koreans, Pacific Islanders); and 4) Africans (sub-Saharan). The [ANCESTRYBYDNATM] 3.0 test can further distinguish between South Asian and European, and between Pacific Islander and East Asian, thus providing 6 proportions (Native American, European, African, South Asian, East Asian and Pacific Islander), although the confidence intervals are larger than those obtained with the [ANCESTRYBYDNA] 2.0 test. Further improvement to the tests are provided, wherein the confidence intervals are reduced. Confidence intervals around a point estimate can be reduced, thus increasing the accuracy of the test, by analyzing a complementary panel, thereby improving the confidence intervals by about 50%.

Later,
W2P