Anavex Life Sciences Corp (AVXL)

[Investor2014]

Well the main issue was the strong placebo response, so I find it hard to make sense of your question.

Were there more placebo girls that dropped out, as they showed little or no significant improvement and drop out after 4 weeks with their numbers being excluded from Week 4 as well as Week 12?

Per Kaufman the issue is believed to be a disproportionate (poor) baseline scores in the placebo versus dose arm patients. This could happen simply be chance especially in a small trial. In any event dropouts must be accounted for including their baseline scores and any missing trial duration data, which the statistical methods used should ensure.