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falconer66a

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falconer66a

Re: bas2020 post# 437055

Wednesday, 10/25/2023 10:48:36 PM

Wednesday, October 25, 2023 10:48:36 PM

Post# of 462128
Maybe even better in humans.

Would the half-lives of 3-71 and its metabolite be the same in both mice and humans, or would they be "sped up" in mice because of the a higher metabolism?


The metabolic rates and renal and hepatic waste clearance rates of rats can’t be much different from humans. But if they are, I don’t see that it would make much difference. In fact, if rats metabolized or cleared Anavex 3-71 faster than humans, it means that humans would have even better and longer duration outcomes with the drug.
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