NorthWest Biotherapeutics Inc (NWBO)

[hyperopia]

Here’s my thoughts: Dr. Bosch’s ASCO presentation was next level, and a highpoint for the presentations that I’ve seen. I think it provided definitive proof that DCVax actually works as theorized . . . a proven mechanism of action that establishes an immune response, which harnesses the power of the human immune system to overcome most cancers, and potentially many other diseases.

First providing the evidence through scientific studies, and then demonstrating this fact with real patients, (who were in the audience) and showing their brain scans, was a powerful message, and it was appreciated, and received applause from the audience.

Additionally, he quashed the criticisms of a few detractors, who are professionally or financially conflicted, by providing the rationale for using external controls, and demonstrating that Northwest Bio’s statistical methods were valid, (currently used by European governments in their economic decision making) and showing how they removed potential biases.

Further thoughts: what is really incredible, and what many people don’t realize, is that Northwest Bio actually knows how to make DCVax much more potent (10x) than was used in the phase 3 clinical trial, and they own the patents for this process.

When you think about the possibilities of various combinations with, toll-like receptor agonists (poly ICLC), colony stimulating factor receptor (CSF-1R) inhibitors, checkpoint inhibitors, etc., to increase responders, and using gene sequencing and advanced proteomics analysis for profiling molecular alterations in various diseases, it seems like the holy grail - i.e., potential cures for cancer and other diseases.

DCVax is a platform that, when produced with their low-cost automated cell manufacturing and digital batch verification systems, could eventually make the owner of this technology, one of the richest biotech companies in the world.