Thursday, June 08, 2023 1:12:30 PM
The major difference between MT-501 and MT-601 is adding WT1 (Wilm's tumor gene 1) to the cocktail. WT1 is not normally expressed in lymphocytes and many other normal tissues. WT1 is one of the most widespread tumor antigens present in many human malignancies, including lymphoma, AML and approximately 30+% of solid tumors.Therefore, it was a smart move for MRKR to add WT1 to maximize its anti-cancer potential in a much wider spectrum of cancer types.
Among hematopoietic cancers, WT1 RNA expression was detected in 90% chronic myeloid leukemia (CML), 87% of acute myeloid leukemia (AML), 68% acute lymphoblastic leukemia (ALL) and 30% of malignant lymphomas. Among lymphoma, WT1 expression is usually found in higher grade lymphoma with aggressive behaviors and worst prognosis. For example, WT1 expression was found in 80% Burkitt lymphomas, 75% ALK-positive ALCL, 45% ALK-negative ALCL, 50% lymphoblastic lymphomas, and 33% DLBCL.
Among solid tumors, WT1 expression was seen in approximately 1/3 of all solid tumors. The expression of WT1 is seen in ovarian serous carcinoma (95%), malignant mesothelioma (85%), pancreatic cancer (78%), uterine sarcoma (75%), glioblastoma (68%), lung NSCLC (50%), breast cancer (30%), and endometrial cancer (25%).
Recent MRKR pre-clinical study to show MT-601 effectiveness in lymphoma is very encouraging, given that lymphoma is not a high expressor for WT1 (only those 30% of highly aggressive lymphomas). I definitely anticipate better, or at least equivalent, results in AML or pancreatic cancer.
Have a wonderful day everyone!
Recent MRKR News
- Korro Announces Addition of Industry Veteran Katharine Knobil to and Resignation of David Lucchino From Its Board of Directors • GlobeNewswire Inc. • 08/28/2024 12:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/14/2024 08:47:43 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/14/2024 08:39:13 PM
- Marker Therapeutics Reports Second Quarter 2024 Financial Results and Provides Business Updates • GlobeNewswire Inc. • 08/14/2024 08:30:58 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/12/2024 11:12:59 AM
- Marker Therapeutics Awarded $2 Million Grant from NIH in Support of Phase 1 Study Investigating MT-601 in CAR-Relapsed Patients with Non-Hodgkin’s Lymphoma • GlobeNewswire Inc. • 08/12/2024 11:00:57 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/12/2024 08:05:47 PM
- Form SC 13D/A - General statement of acquisition of beneficial ownership: [Amend] • Edgar (US Regulatory) • 05/17/2024 10:25:14 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/15/2024 08:40:16 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/15/2024 08:03:21 PM
- Principal Investigator from City of Hope National Medical Center Invited to Present Clinical Data from Marker Therapeutics APOLLO Study at 11th Global Summit on Hematologic Malignancies • GlobeNewswire Inc. • 04/08/2024 11:00:39 AM
- Marker Therapeutics Reports Year-End 2023 Corporate and Financial Results • GlobeNewswire Inc. • 03/25/2024 09:45:00 PM
- Marker Therapeutics to Present at the H.C. Wainwright 2nd Annual Cell Therapy Virtual Conference • GlobeNewswire Inc. • 03/22/2024 04:30:51 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/01/2024 01:02:47 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/26/2024 12:58:51 PM
- Marker Therapeutics Receives Approval from United States Adopted Name (USAN) Council and International Nonproprietary Names (INN) Expert Committee for “Neldaleucel” as Nonproprietary Name for MT-601 • GlobeNewswire Inc. • 01/22/2024 12:30:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/08/2024 01:30:48 PM
- Marker Therapeutics Announces Clinical Program Updates and Pipeline Prioritization • GlobeNewswire Inc. • 01/08/2024 01:24:49 PM
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- Form 8-K - Current report • Edgar (US Regulatory) • 12/11/2023 12:35:22 PM
- Marker Therapeutics Announces Sustained Complete Response in First Lymphoma Patient Treated with MT-601 following CAR T Relapse • GlobeNewswire Inc. • 12/11/2023 12:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/20/2023 09:37:41 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/09/2023 10:03:53 PM
- Marker Therapeutics Reports Third Quarter 2023 Financial Results and Provides Business Updates • GlobeNewswire Inc. • 11/09/2023 10:00:00 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/09/2023 09:31:53 PM
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