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[Joseph_K]

Two people with genetic mutation for Alzheimer's have brains full of amyloid plaque, but not dementia.

You're likely familiar with the extended family in Colombia that is famous because a large percentage of its members have a gene mutation that dooms them to severe dementia before they turn 50. A report in the journal Nature Medicine says researchers have recently identified a second person who has the gene mutation but did not develop dementia (or only mildly and not until many years older than all the other carriers of the mutation).

Here's the interesting part:

What’s more, both patients had brains riddled with amyloid plaques, which have so far been a key target in therapies for Alzheimer’s.

They had a gene that guaranteed Alzheimer's, their brains were "clogged with the characteristic amyloid plaques of Alzheimer’s," but neither had dementia. I think these findings likely say something about the amyloid hypothesis.

https://www.washingtonpost.com/science/2023/05/15/alzheimers-disease-treatments/