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Wednesday, April 26, 2023 12:27:57 AM
And who said that the RSV trial was a failure? Not I.
You are concluding it was a failure simply because the "healthies" recovered at a rate similar to those administered ENTA's RSV drug. You seem to conclude then that *therefore* it cannot work on other groups of immuno compromised/suppressed groups (young, old, immuno compromised)
As far as RSV, EDP-938 showed good efficacy in the phase 2 trial in healthy adults with regards stop reducing viral load and had a good safety profile. However, RSV resolved quickly even in placebo, which was not unexpected. The trial in immunocompromised patients and the very young are the acid test. Keep in mind that a second anti-RSV drug, EDP-323, has gotten fast track status so may be used alone of in a combo with EDP-938 down the road. Still a lot of questions to be addressed but clearly not a failure.
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