NorthWest Biotherapeutics Inc (NWBO)

[hyperopia]

That’s a reasonable suggestion flipper, but it’s been my observation that, while Dave serves a valuable purpose, he’s been unable to answer seemingly immaterial questions in a direct manner, so I haven’t talked with him in a couple years. In this case, it could reveal a commercialization strategy.

I thought that Northwest Bio was planning a slow (go-it alone) commercialization rollout only in the UK this year to work out the commercialization kinks, and then later next year expand to the US. Using fresh monocytes, and regional manufacturing would be fine for this type of commercial startup. However, if Linda is taking about global distribution, and redundant manufacturing, possibly implying a much larger commercial rollout, (potentially with a strategic partner say for Project Orbis) then cryopreserving leukapheresis material would absolutely be necessary. Let’s hope that Advent has been working on this since before I first raised the issue in 2021.

By the way, the first approved CAR-T manufacturers (Kite & Novartis) both cryopreserved their leukapheresis material early in clinical trial development, in recognition of the eventual logistical necessity for global distribution.